Author

R. Dick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Engelman· 1 shared A. Tan· 1 shared B. Feierbach· 1 shared B. Runge· 1 shared C. Aiken· 1 shared C. H. Tay· 1 shared C. Snyder· 1 shared C. Xu· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. Engelman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding

J. C. V. Stacey, A. Tan, J. M. Lu, L. C. James, R. Dick, J. A. G. Briggs

This study identifies two structural switches in HIV-1 capsid protein that modulate host factor binding based on capsid curvature and oligomerization state.

bioRxiv · Dec 2, 2022Microbiology

Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus

U. Schmitz, S. A. Gilmore, D. Tam, T. L. Cheung, C. Snyder, J. Farand, R. Dick, M. Matles, J. Y. Feng, R. Ramirez, L. Li, H. Yu, Y. Xu, D. Barnes, G. Czerwieniec, , B. Feierbach

This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.

bioRxiv · Jun 27, 2022 · PreprintPharmacology & Toxicology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

bioRxiv · Apr 30, 2020Biophysics