Author

B. Ruple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Roberts· 3 shared A. Agyin-Birikorang· 2 shared A. Fruge· 2 shared C. B. Mobley· 2 shared D. Plotkin· 2 shared J. Godwin· 2 shared J. M. Michel· 2 shared M. Mattingly· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

M. Roberts

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Author profile →

3 papers

Recent·Most cited

The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

B. Ruple, M. Mattingly, J. Godwin, M. McIntosh, N. Kontos, A. Agyin-Birikorang, J. M. Michel, D. Plotkin, S.-Y. Chen, T. Ziegenfuss, A. Fruge, L. B. Gladden, A. Robinson, C. B. Mobley, A. L. Mackey, M. Roberts

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

bioRxiv · Oct 4, 2023Physiology

A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training

M. Roberts, B. Ruple, J. Godwin, M. McIntosh, S.-Y. Chen, N. Kontos, A. Agyin-Birikorang, J. M. Michel, D. Plotkin, M. Mattingly, C. B. Mobley, T. Ziegenfuss, A. Fruge, A. Kavazis

This study uses a novel deep proteomic approach to analyze aging and resistance training effects on skeletal muscle proteomes, revealing distinct molecular changes in myofibrillar and non-myofibrillar fractions.

bioRxiv · Jun 2, 2023Physiology

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

C. Vann, C. Sexton, S. Osburn, M. Smith, C. Haun, M. Rumbley, P. Mumford, B. Ferguson, N. Montgomery, C. Fox, B. Ruple, J. McKendry, J. McLeod, A. Bashir, R. Beyers, , M. Roberts

This study compares high-volume and high-load resistance training on muscle growth and molecular markers, finding similar hypertrophic and strength adaptations despite differences in protein synthesis rates.

bioRxiv · Jul 1, 2021Physiology