J. Godwin

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training

This study uses a novel deep proteomic approach to analyze aging and resistance training effects on skeletal muscle proteomes, revealing distinct molecular changes in myofibrillar and non-myofibrillar fractions.

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.

This paper shows MCPH1 inhibits condensin II during interphase by binding to NCAPG2, preventing chromosome condensation, and demonstrates that this regulation is essential for maintaining chromatin structure.

A polyglutamine domain is required for de novo CIZ1 assembly formation at the inactive X chromosome

The paper shows that a polyglutamine domain in CIZ1 is required for forming de novo assemblies at the inactive X chromosome, mediated by interactions with Xist RNA.

TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemia

This paper shows TP53 mutations in AML are linked to immune features and improved response to flotetuzumab immunotherapy.

Loss of Sister Kinetochore Co-orientation and Peri-centromeric Cohesin Protection after Meiosis I Depends on Cleavage of Centromeric REC8

The paper shows that cleavage of REC8 in meiosis I is essential for sister kinetochore co-orientation loss and peri-centromeric cohesin deprotection, which are necessary for sister chromatid disjunction.

Locally Fixed Alleles: A method to localize gene drive to island populations

This paper proposes a gene drive method to localize population elimination to island populations by targeting locally fixed alleles, showing limited spread to non-target populations.