PhysiologybioRxiv
A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).
B. Shalomov, R. Handklo-Jamal, H. P. Reddy…·N. Dascal
This study shows that cytosolic domain mutations in GIRK4 (KCNJ5) cause loss-of-function rather than gain-of-function, challenging the existing mechanism of hyperaldosteronism.
DOI 10.1113/jp282690