Author

N. Dascal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Assay:electrophysiology· 4 Organism:Xenopus· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Katz· 3 shared O. Chomsky-Hecht· 3 shared B. Shalomov· 2 shared E. Klussmann· 2 shared H. P. Reddy· 2 shared J. Hirsch· 2 shared S. Subramaniam· 2 shared S. Weiss· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPhysiology

M. Katz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ethosuximide: subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels

B. Shalomov, T. Friesacher, D. Yakubovich, J. C. Combista, H. P. Reddy, S. Dabbah, H. Bernsteiner, E.-M. Zangerl-Plessl, A. Stary-Weinzinger, N. Dascal

This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.

bioRxiv · Jun 4, 2024Pharmacology & Toxicology

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel modulate its β-adrenergic regulation

S. Oz, T. Sharon, S. Surbramaniam, T. Pallien, M. Katz, V. Tsemakhovich, D. R. Tripathy, G. Sasson, O. Chomsky-Hecht, L. Vysochek, M. Schulz, C. Fecher-Trost, K. Zuhlke, D. Bertinetti, F. W. Herberg, , N. Dascal

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.

bioRxiv · Nov 28, 2023 · PreprintBiochemistry

Mapping molecular determinants of Cav2.2 inhibition by RGK proteins and homologs in Xenopus oocytes

Y. Sasson, S. Subramaniam, T. Buki, L. Almagor, O. Chomsky-Hecht, M. Katz, H. Puhl, S. R. Ikeda, N. Dascal, J. Hirsch

This study identifies structural determinants in RGK proteins that inhibit CaV2.2 channels in Xenopus oocytes, showing key regions in the G-domain and C-terminus are critical for this inhibition.

bioRxiv · Jun 21, 2022 · PreprintPhysiology

Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

M. Katz, S. Subramaniam, O. Chomsky-Hecht, V. Tsemakhovich, A. Belkacemi, V. Flockerzi, E. Klussmann, J. Hirsch, S. Weiss, N. Dascal

This study reconstitutes the β-adrenergic regulation of CaV1.2 channels in a heterologous system, identifying Rad-dependent and Rad-independent PKA mechanisms.

bioRxiv · Nov 30, 2020Physiology

A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).

B. Shalomov, R. Handklo-Jamal, H. P. Reddy, N. Theodor, A. K. Bera, N. Dascal

This study shows that cytosolic domain mutations in GIRK4 (KCNJ5) cause loss-of-function rather than gain-of-function, challenging the existing mechanism of hyperaldosteronism.

bioRxiv · Dec 9, 2019Physiology