Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts
A. Sathe, K. Mason, S. M. Grimes, Z. Zhou, B. T. Lau, X. Bai, A. Su, X. Tan, H. Lee, C. Suarez, Q. Nguyen, G. Poultsides, N. Zhang, H. P. Ji
This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.
bioRxiv · Sep 1, 2020Cancer Biology