C. Suarez

Evaluation of homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional tissue-based immunofluorescence assays

This study evaluates homologous recombination repair status in metastatic prostate cancer using next-generation sequencing and RAD51 immunofluorescence assays, finding strong correlation between genomic and functional HRR loss.

Multi-monoubiquitination controls VASP-mediated actin dynamics

This study shows that multi-monoubiquitination of VASP at specific lysine residues negatively regulates its actin-binding and bundling activities, affecting cell spreading morphology.

The actin assembly requirements of the formin Fus1 to build the fusion focus

This study investigates how the nucleation and elongation rates of the formin Fus1 affect the formation of the actin fusion focus in fission yeast, showing that native rates are optimal for this structure.

Disturbance-based management of ecosystem services and disservices in partial nitritation anammox biofilms

The paper shows that disturbances can alter functional redundancy in PNA biofilms by affecting Nitrospira, Brocadia, and Nitrosomonas differently, suggesting disturbance-based management for wastewater treatment.

Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

Diversity and gene expression patterns of functional groups in sidestream and mainstream wastewater partial-nitritation anammox biofilms

The paper compares microbial communities in sidestream and mainstream wastewater PNA biofilms, finding differences in functional group composition and activity despite similar dominant species.

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

This study identifies a conserved mechanism by which LIM domains bind stressed actin filaments across species, revealing their role in sensing mechanical strain.

Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment

This study uses single-cell RNA sequencing to analyze gastric cancer tumor microenvironment, identifying reprogramming in immune and stromal cells and novel molecular targets for immunotherapy.

Mechanical and kinetic factors drive sorting of F-actin crosslinkers on bundles

The paper investigates how mechanical and kinetic factors influence the sorting of F-actin crosslinkers on bundles, showing a non-monotonic dependence on polymerization rate.

Biofilm thickness matters: Deterministic assembly of different functions and communities in nitrifying biofilms

This study shows that biofilm thickness significantly affects community composition and ecosystem function in nitrifying biofilms.