X. Bai

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides

The paper develops MILTS, a teacher-student framework for predicting PDL1 expression from H&E slides using weakly supervised learning, achieving high AUC scores across multiple tumor types.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers

The paper examines GITR and TIGIT immunotherapies in gastrointestinal cancers using ex vivo cultures and single-cell sequencing to identify their cellular mechanisms in the tumor microenvironment.

FK506 binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium

This study identifies Fkbp5 as a regulator of epithelial cell quiescence-proliferation transition via Akt signaling in zebrafish using transcriptomics and genetic approaches.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

Structural basis for the Rad6 activation by the Bre1 N-terminal domain

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Distinct cell states define the developmental trajectories of mucinous appendiceal neoplasms towards pseudomyxoma metastases

This study uses single-cell RNA-sequencing to identify distinct cell states in appendiceal mucinous neoplasms and their progression to pseudomyxoma peritonei, revealing developmental trajectories and signaling pathway changes.

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

Time-series monitoring of transgenic maize seedlings phenotyping exhibiting glyphosate tolerance

This study develops a hyperspectral imaging-based method to monitor leaf chlorophyll content and assess glyphosate tolerance in maize seedlings using chlorophyll a fluorescence and chemometrics.

Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages

This study identifies AAT binding to the glucocorticoid receptor in macrophages, showing its role in anti-inflammatory and host-defense functions.

Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex

The paper reports cryo-EM structures of a Munc18-1-syntaxin-1-synaptobrevin complex, revealing how Munc18-1 facilitates SNARE complex assembly by mediating interactions between syntaxin-1 and synaptobrevin.

The Influence of Leaf Anatomical Traits on Photosynthetic in Coffee Leaves

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

This study shows low-molecular weight heparins enhance C1-INH activity in HAE patients and in vitro, suggesting they could be a cost-effective treatment for acute HAE.