Author

B. Timalsina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

L. Plate· 2 shared A. Rab· 1 shared C. M. P. Sabusap· 1 shared D. Joshi· 1 shared E. F. McDonald· 1 shared E. J. Sorscher· 1 shared J. N. Hermanson· 1 shared J. S. Hong· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

L. Plate

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Author profile →

2 papers

Recent·Most cited

Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

M. Kim, E. F. McDonald, C. M. P. Sabusap, B. Timalsina, D. Joshi, J. S. Hong, A. Rab, E. J. Sorscher, L. Plate

This study investigates how Elexacaftor/VX-445 affects CFTR interactome remodeling in response to specific mutations, revealing differential correction mechanisms.

bioRxiv · Feb 4, 2023Cell Biology

Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics

M. T. Wright, B. Timalsina, V. A. G. Lopez, J. N. Hermanson, S. Garcia, L. Plate

This study develops TRIP, a mass-spectrometry method to map protein interactions over time, and applies it to study hypothyroidism by analyzing thyroglobulin interactions and identifying VCP and TEX264 as key factors in protein degradation.

bioRxiv · Sep 4, 2022Cell Biology