S. Garcia

Do seabirds dream of artificial lights? Understanding light preferences of Procellariiformes

This study investigates light preferences of Corys shearwater fledglings and adults, finding a preference for no-light and red light, suggesting artificial light disorients seabirds.

Spatial propagation of temperate phages within and among biofilms

The paper tracks temperate phages in biofilms, showing lysogens are over-represented in dispersal pools and have advantages in long-term propagation.

Evolving together: Cassandra retrotransposons gradually mirror promoter mutations of the 5S rRNA genes

This study shows Cassandra retrotransposons gradually co-evolve with 5S rRNA gene promoter mutations in the Asteraceae family, adapting to host transcription factors.

Comparison of commercial DNA extraction kits for whole metagenome sequencing of human oral, vaginal, and rectal microbiome samples

This study compares four DNA extraction kits for whole metagenome sequencing of human oral, vaginal, and rectal microbiome samples, finding systematic biases in microbial taxa representation.

Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics

This study develops TRIP, a mass-spectrometry method to map protein interactions over time, and applies it to study hypothyroidism by analyzing thyroglobulin interactions and identifying VCP and TEX264 as key factors in protein degradation.

Effects of anti-fibrotic standard of care drugs on senescent human lung fibroblasts

This study examines the effects of nintedanib and pirfenidone on senescent lung fibroblasts, finding they do not induce apoptosis and may increase fibrotic markers.

Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

The paper determines the structure of the RAF1-HSP90-CDC37 complex using cryo-EM, revealing how CDC37 regulates RAF1 and potential therapeutic targets.

Humanized mice for sustained Plasmodium vivax blood-stage infection and transmission

This paper develops a humanized mouse model that supports sustained Plasmodium vivax blood-stage infection and transmission to mosquitoes.

Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

The paper investigates how impaired LAIR-1-collagen interaction in fibrosis contributes to inflammation and fibrosis, finding that dysfunctional collagen ligands and matrix metalloproteinases drive disease progression.

Genome-wide analysis of long terminal repeat retrotransposons from the cranberry Vaccinium macrocarpon

This study characterizes LTR retrotransposons in the cranberry genome, identifying their abundance, structure, and activity, and highlights potential markers for breeding.

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

This paper develops a transcriptomic gradient (PAMG) to predict pancreatic cancer aggressiveness and treatment response using patient-derived xenografts and clinical data.

Human-like telomeres in Zostera marina reveal a mode of transition from the plant to the human telomeric sequences

The paper identifies human-like telomeres in Zostera marina, proposes a mechanism for their evolution from plant-type sequences, and introduces a mechanistic model for this transition.

Understanding and eliminating the detrimental effect of endogenous thiamine auxotrophy on metabolism of the oleaginous yeast Yarrowia lipolytica

This study identifies the genetic basis of thiamine auxotrophy in Yarrowia lipolytica and engineers a thiamine-prototrophic strain with enhanced lipid production.

Reconstructing Phylogenetic Relationships Based On Repeat Sequence Similarities

This paper introduces a method using repeat sequence similarities to infer phylogenetic relationships, showing congruence with standard DNA marker-based analyses in plants and insects.

Molecularly distinct models of zebrafish Myc-induced B cell leukemia

The paper compares two zebrafish B cell leukemia models driven by murine or human c-MYC, finding distinct lineage origins and molecular pathway signatures.

Multiobjective Strain Design: A Framework for Modular Cell Engineering

This study introduces ModCell2, a framework for modular cell engineering that optimizes genetic modifications to balance modularity, performance, and robustness in production strains.