Cell BiologybioRxiv
Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics
M. T. Wright, B. Timalsina, V. A. G. Lopez…·L. Plate
This study develops TRIP, a mass-spectrometry method to map protein interactions over time, and applies it to study hypothyroidism by analyzing thyroglobulin interactions and identifying VCP and TEX264 as key factors in protein degradation.
DOI 10.1038/s44320-024-00058-1