D. Joshi

Mechanism of chaperone coordination during cotranslational protein folding in bacteria

The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.

Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development

This paper shows Rudhira regulates TGFβ signaling and microtubule stability during mouse vascular development through both direct and transcriptional mechanisms.

Evaluation Of Suitability Analysis of Gangetic Water from Upper, Middle, And Lower Ganga Rivers

This study evaluates water quality across the Ganga River's upper, middle, and lower stretches to determine suitability for drinking, irrigation, and industrial use, highlighting variations in parameters like E. coli, sodium levels, and heavy metals.

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation

The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

This study investigates how Elexacaftor/VX-445 affects CFTR interactome remodeling in response to specific mutations, revealing differential correction mechanisms.

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

Corona virus fear among health workers during the early phase of pandemic response in Nepal: a web-based cross-sectional study

This study assesses factors associated with COVID-19 fear among Nepalese health workers during the pandemic's early phase using a web-based survey.

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

This study shows that SGS mutations in SKI prevent its binding to phosphorylated SMAD2/3, leading to SKI stabilization and reduced TGF-β responses.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.