Distinct states of proinsulin misfolding in MIDY
L. Haataja, A. Arunagiri, A. Hassan, K. Regan, B. Tsai, B. Dhayalan, M. A. Weiss, M. Liu, P. Arvan
The paper investigates proinsulin misfolding in MIDY mutants, showing that disrupting the Cys(A6)-Cys(A11) bond can restore proper folding and ER export in some mutants.
bioRxiv · May 10, 2021Biochemistry