D. Dong

Immune-profiling of T helper 1 (Th1), Th2 and Th17 signatures in murine splenocytes by targeting intracellular cytokines

The paper develops a 17-parameter spectral flow cytometry panel to profile Th1, Th2, and Th17 cytokine signatures in murine splenocytes under steady-state and stimulated conditions.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

SlSAURs, targeted by SlSTOP1, inhibit SlPP2C.Ds to modulate H+-ATPase and tomato root elongation under aluminum stress

This study identifies SlSAURs as regulators of root elongation under aluminum stress by interacting with SlPP2C.Ds to modulate H+-ATPase activity.

Melatonin serves as a novel treatment in cystic fibrosis and inhibits cystic fibrosis through TGF-β1/Smad and EMT

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stability

This study shows IL-16 promotes atherosclerotic plaque stability by upregulating TIMP-3 through STAT6 and CBP/p300 recruitment.

FAN, the homolog of mammalian Apoptosis Antagonizing Transcription Factor AATF/Che-1 protein, is involved in safeguarding genome stability through the ATR induced pathway in Arabidopsis

This study identifies FAN, a homolog of AATF/Che-1 in Arabidopsis, as essential for genome stability through the ATR-induced DNA damage response pathway.

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Self-Supervised Maize Kernel Classification and Segmentation for Embryo Identification

This paper applies self-supervised learning to maize kernel classification and segmentation, showing improved performance and annotation efficiency compared to supervised methods.

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

Phase separation of Mer2 organizes the meiotic loop-axis structure of chromatin during meiosis I

This study shows Mer2 phase separation forms droplet-loop chromatin structures to enable diverse meiotic DSB formation.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

Nucleolin is essential for rabbit hemorrhagic disease virus replication by providing a physical link in replication complex formation

This study identifies nucleolin as essential for RHDV replication by facilitating the formation of replication complexes through interactions with viral proteins.

Diverse functions of closely homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence.

The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.