A ciliopathy complex builds distal appendages to initiate ciliogenesis
D. Kumar, A. Rains, V. Herranz-Perez, Q. Lu, X. Shi, D. L. Swaney, E. Stevenson, N. J. Krogan, B. Huang, C. Westlake, J. M. Garcia-Verdugo, B. Yoder, J. Reiter
The paper identifies the DISCO complex, essential for ciliogenesis, and shows its role in distal appendage formation and centriole length regulation, linking defects to human ciliopathies.
bioRxiv · Mar 1, 2021Cell Biology