D. L. Swaney

Defining the constituents and functions of a lipid-based jumbo phage compartment

The paper identifies a lipid-based compartment in early phage infection that protects phage DNA and supports early transcription and translation.

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to displace native TRAF7 interacting partners

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

Epigenetic reprogramming shapes the cellular landscape of schwannoma

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

The paper introduces a multi-scale proximity labeling method using Eosin Y to map cell surface protein neighborhoods at varying resolutions and validates interactions of EGFR and CAR-T cell synapses.

Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila

This study identifies how Legionella pneumophila modifies host ubiquitination during infection, revealing widespread monoubiquitination of small GTPases and the role of SidC/SdcA effectors.

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

This paper identifies SidI, a Legionella toxin that mimics tRNA, glycosylates the translation machinery, and triggers a ribotoxic stress response leading to cell death.

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism

This study identifies two PKA-driven oncogenic mechanisms, showing AURKA stabilizes MYC oncoproteins through a PIM2-mediated feedback loop, and suggests CD-532 as a potential therapeutic target.

A ciliopathy complex builds distal appendages to initiate ciliogenesis

The paper identifies the DISCO complex, essential for ciliogenesis, and shows its role in distal appendage formation and centriole length regulation, linking defects to human ciliopathies.

Cardiac Cell-Derived Matrices Impart Age-Specific Functional Properties to Human Cardiomyocytes

The paper develops a method to create stable cardiac cell-derived matrices and shows that fetal and adult matrices impart distinct functional properties to cardiomyocytes, with collagen VI in fetal matrices enhancing oxidative respiration.

Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

This study profiles host cell proteome, ubiquitinome, and phosphoproteome during Legionella pneumophila infection, revealing modulation of mitochondrial stress response pathways.

Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

The paper identifies NOSEMPE in brown adipocytes as a cause of mitochondrial ETC imbalance and shows it drives nonmitochondrial thermogenesis and metabolic improvement via ATF4 activation.