Reducing phenotypic instabilities of microbial population during continuous cultivation based on cell switching dynamics
T. M. Nguyen, S. Telek, A. Zicler, J. A. Martinez, B. Zacchetti, J. Kopp, C. Slouka, C. Herwig, A. Gruenberger, D. Frank
This paper demonstrates that allowing microbial cells to switch phenotypes around a threshold, rather than enforcing a fixed trajectory, leads to more stable population behavior during continuous cultivation.
bioRxiv · Jan 13, 2021Microbiology