NeuroscienceDisease Models & MechanismsPeer-reviewed
SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis
Kriti Chaplot, Lokesh G. Pimpale, Balaji Ramalingam…·Girish S. Ratnaparkhi
The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.
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