High fat diet promotes obesity by driving miRNA dependent neurogenesis and integration of orexigenic neurons in the feeding circuitry
Balakumar Srinivasan, Sarbani Samaddar, Himanshu Singh…·Sourav Banerjee
This study shows that high-fat diet induces miRNA-dependent neurogenesis in hypothalamic tanycytes, leading to weight gain and liver fat accumulation by promoting the integration of orexigenic neurons into the feeding circuit.