NeuroscienceNaturePeer-reviewed
Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice
Matthew S. Elitt, Lilianne Barbar, H. Elizabeth Shick…·Paul J. Tesar
This paper shows that reducing PLP1 expression in a mouse model of PMD improves myelination, motor function, and lifespan, supporting PLP1 suppression as a therapeutic strategy.
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