Cancer BiologyFrontiers in ImmunologyPeer-reviewed
Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
Mónica Cruz-Barrera, Joshua Dulong, Georgio Mansour Nehmo…·Christian M. Beausejour
The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.