Anthony Sonn

This study shows senescent fibroblasts in humanized mouse models promote tumor progression by inducing neutrophil extracellular traps (NETs) that impair immune responses.

The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.

This study shows that T lymphocytes from Crohn's disease patients impair intestinal epithelial integrity through increased cytotoxicity and altered immune responses in a 3D coculture model.