ImmunologybioRxivPreprint
GSK-3 regulates CD4-CD8 cooperation needed to generate super-armed CD8+ cytolytic T cells against tumors
Bastien Moës, Janna Krueger, Alexandra Kazanova…·Christopher E. Rudd
This study shows GSK-3 enhances PD-1 blockade by promoting CD4-CD8 T-cell cooperation, leading to more effective anti-tumor CD8+ cytolytic T cells.
DOI 10.1101/2025.03.08.642085