Belquis Nassim-Assir

This study profiles mRNA and protein changes in excitatory and inhibitory synapses of Fmr1-deficient mice, revealing cell type-specific molecular alterations and opposing protein changes due to FMRP loss.

The paper identifies localized mRNAs and proteins in cortical layer 1 synapses, showing specialized transcriptomes and suggesting local translation supports layer-specific functions.

The paper integrates transcriptomic and proteomic data from mouse hippocampal regions and synapses to reveal molecular diversity and co-regulation patterns.

This paper introduces a multicopy MetRS* mouse line to enhance cell type-specific in vivo protein labeling, enabling sensitive detection of newly synthesized proteins in sparse cell populations.

The paper identifies a proteasomal 19S subcomplex that regulates neuronal synapses independently of the 20S catalytic subunit through deubiquitylation of Lys63-ubiquitin.

The paper identifies and quantifies the transcriptome and translatome in neuronal cell bodies, dendrites, and axons using RNA-seq and Ribo-seq, revealing that local translation is a major source of synaptic proteins.