Molecular BiologyNature CommunicationsPeer-reviewed
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
Andrés Tapia del Fierro, Bianca den Hamer, Natalia Benetti…·Marnie E. Blewitt
This study identifies a mutation in SMCHD1 that enhances gene silencing and disrupts developmental processes, revealing distinct roles of SMCHD1 in chromatin structure and gene regulation.