Cancer BiologybioRxivPreprint
TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment
Shengliang Zhang, Kelsey E. Huntington, Lanlan Zhou…·Wafik S. El‐Deiry
This study investigates how senescent fibroblasts influence tumor growth and immune response, showing that targeting the p21-driven SASP and combining senolytics with cancer therapies can suppress tumor growth.
DOI 10.1101/2023.11.30.569479