Author

Jill A. Kreiling

Brown UniversityORCID 0000-0003-4440-2039Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Animal Behavior & Cognition· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:behavioral assay· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

John M. SedivyiD· 2 shared Robbert CrétoniD· 2 shared Sayali V. GoreiD· 2 shared Thaís Del Rosario HernándeziD· 2 shared Abhirup DasiD· 1 shared Alice E. KaneiD· 1 shared Amy J. WagersiD· 1 shared Ana-Maria BaltaiD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

John M. SedivyORCID

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4 papers

Recent·Most cited

Animal Behavior & CognitionBiomedicine & PharmacotherapyPeer-reviewedDec 1, 2024

Combining supervised and unsupervised analyses to quantify behavioral phenotypes and validate therapeutic efficacy in a triple transgenic mouse model of Alzheimer's disease

Thaís Del Rosario Hernández, Narendra R. Joshi, Sayali V. Gore…·Robbert Créton

The paper validates the therapeutic effects of cyclosporine A and candidate drugs in a 3xTg-AD mouse model using combined supervised and unsupervised behavioral analysis.

2 citations

mousebehavioral assay

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Animal Behavior & CognitionBiomedicine & PharmacotherapyPeer-reviewedJan 6, 2024

Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles

Thaís Del Rosario Hernández, Sayali V. Gore, Jill A. Kreiling, Robbert Créton

The paper identifies 64 drug candidates for neurodegenerative diseases by screening FDA-approved drugs using zebrafish behavioral profiles generated by a neural network model.

19 citations

zebrafishbehavioral assay

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Cancer BiologybioRxivPreprintNov 30, 2023

TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

Shengliang Zhang, Kelsey E. Huntington, Lanlan Zhou…·Wafik S. El‐Deiry

This study investigates how senescent fibroblasts influence tumor growth and immune response, showing that targeting the p21-driven SASP and combining senolytics with cancer therapies can suppress tumor growth.

DOI 10.1101/2023.11.30.569479

humanexperimental assay

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Molecular BiologybioRxivPreprintOct 21, 2019

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski…·David A. Sinclair

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

24 citations

mouseDNA methylation

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