Bin Hu

A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention

This study shows that combining sacituzumab govitecan with the senolytic ABT-263 effectively overcomes chemoresistance in HNSCC by targeting senescent cells.

Daraxonrasib (RMC-6236) is an effective targeted therapy for RAS-mutant neuroblastoma

This study shows that Daraxonrasib (RMC-6236) effectively targets RAS-mutant neuroblastoma by inhibiting MAPK signaling and enhancing cell death.

Diet-Driven Gut Microbiome Differences Between Cohabiting Han and Yi Ethnic Groups in Liangshan, China

This study compares gut microbiota differences between Han and Yi ethnic groups in China, finding diet, not genetics, drives microbial composition differences despite shared environment.

A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

Expanding the HDAC druggable landscape beyond enzymatic activity

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.