Author

Minghui Wang

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetic & Genomic Medicine· 2 Neuroscience· 2 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:database / resource· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Bin Zhang· 3 shared David A. A BennettiD· 3 shared Michelle E. EhrlichiD· 3 shared Philip L. De JageriD· 3 shared Carlos CruchagaiD· 2 shared Hans‐Ulrich KleiniD· 2 shared Hao H. SuniD· 2 shared Aiqun LiiD· 1 shared

Activity by Year

2019-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Bin Zhang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease

Erming Wang, Boer Xie, Minghui Wang, Yingxue Fu, Xusheng Wang, Yuxin Li, Peng Xu, Huaping Liu, Lap Ho, Zhidong Tu, Charles V. Mobbs, Chris Gaiteri, Michelle E. Ehrlich, David A. A Bennett, Vahram H. Haroutunian, , Bin Zhang

The paper develops a multi-omics cohort of prefrontal cortex data from cognitively normal older adults to identify molecular signatures of cognitive resilience to Alzheimer's disease.

bioRxiv · Sep 6, 2026 · PreprintGenomics

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation

Jeffrey Cifello, Ru Feng, Francis P. Grenn, Luke Carter, Anjing Liu, Hao H. Sun, Ruixi Li, Jenny A Empawi, Emily Greenfest‐Allen, Živadin Katanić, Otto Valladares, Amanda B. Kuzma, Heather White, Lindsay A. Farrer, Alison Goate, , Yuk Yee Leung

The paper presents an xQTL atlas of regulatory variation in the aging human brain, integrating multiple modalities and cell types across four studies, identifying more variant-molecular-trait associations by including TAD boundaries.

medRxiv · Jun 20, 2026 · PreprintGenetic & Genomic Medicine

A Multi-Context Regulome-Wide Association Atlas for Genetic Studies of Aging Brain Disorders

Chunming Liu, Anqi Wang, Hao H. Sun, Kaixuan Luo, Sheng Qian, Yining Li, Daniel C. Nachun, Xin He, Philip L. De Jager, David A. A Bennett, Minghui Wang, Carlos Cruchaga, Gao Wang, Fabio Morgante

This paper introduces FGMB, a multi-context regulome-wide association atlas, and applies it to Alzheimer's disease to identify 327 regulatory associations and resolve 86 gene-molecular-trait pairs.

medRxiv · Jun 17, 2026 · PreprintGenetic & Genomic Medicine

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Kumar Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, , Michelle E. Ehrlich

This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.

Alzheimer s & Dementia · Jun 1, 2026Peer-reviewedNeuroscience

A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease

Natacha Comandante-Lou, Tsering D Lama, Sarah E. Heuer, Kevin W. Chen, Jinho Kim, Jinglong Zhang, Bin Hu, Shuhui Liu, Swagata Dey, Kristen Brennand, Julie A. Schneider, Lisa L. Barnes, Bin Zhang, Minghui Wang, Hongyan Zou, , Philip L. De Jager

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

bioRxiv · Feb 24, 2025 · PreprintNeuroscience

Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models

Ying‐Wooi Wan, Rami Al-Ouran, Carl Grant Mangleburg, Tom V. Lee, Katherine Allison, Sarah Neuner, Catherine Kaczorowski, Vivek Phillip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Jungwoo Wren Kim, Valina Dawson, Ted Dawson, Ping‐Chieh Pao, , Joshua M Shulman

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.

bioRxiv · Jan 3, 2019 · PreprintSystems Biology