Author

Kevin W. Chen

Columbia University Irving Medical CenterORCID 0000-0002-7370-3642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

David Alan BennettiD· 2 shared Hans‐Ulrich KleiniD· 2 shared Mariko F. TagaiD· 2 shared Masashi FujitaiD· 2 shared Philip L. De JageriD· 2 shared Vilas MenoniD· 2 shared Yiyi MaiD· 2 shared Aiqun LiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

David Alan BennettORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 27, 2025

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

Victoria S. Marshe, John F. Tuddenham, Kevin W. Chen…·Philip L. De Jager

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

13 citations

humanscRNA-seq

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NeurosciencebioRxivPreprintFeb 24, 2025

A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease

Natacha Comandante-Lou, Tsering D Lama, Sarah E. Heuer…·Philip L. De Jager

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

14 citations

humanmouse

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