A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease
Natacha Comandante-Lou, Tsering D Lama, Sarah E. Heuer, Kevin W. Chen, Jinho Kim, Jinglong Zhang, Bin Hu, Shuhui Liu, Swagata Dey, Kristen Brennand, Julie A. Schneider, Lisa L. Barnes, Bin Zhang, Minghui Wang, Hongyan Zou, , Philip L. De Jager
The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.
bioRxiv · Feb 24, 2025 · PreprintNeuroscience