ImmunologybioRxivPreprint
Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint Blockade
Duncan M. Morgan, Brendan L. Horton, Maria Zagorulya…·Stefani Spranger
This study identifies spleen-resident intermediate-exhausted T cells as key to ICB efficacy, showing their expansion and differentiation into tumor-infiltrating clonotypes.