Cancer BiologybioRxivPreprint
Ultrasound-mediated mechanical forces selectively kill tumor cells
A. Tijore, F. Margadant, M. Yao…·M. Sheetz
This paper shows low-frequency ultrasound selectively kills tumor cells via a calpain-dependent mitochondrial pathway involving Piezo1 channels, with minimal damage to normal cells in animal models and patient-derived organoids.
DOI 10.1101/2020.10.09.332726