Author

F. Margadant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

M. Sheetz· 2 shared S. Powell· 2 shared A. Hariharan· 1 shared A. Maisha· 1 shared A. Tijore· 1 shared B. Blair· 1 shared B. Rasmussen· 1 shared C. A. Z. Chew· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

M. Sheetz

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2 papers

Recent·Most cited

Rejuvenation of Senescent Cells by Low Frequency Ultrasound without Senolysis

S. K. Kureel, R. Maroto, S. Powell, F. Margadant, B. Blair, A. Maisha, B. Rasmussen, M. Sheetz

Low-frequency ultrasound rejuvenates senescent cells by reversing 15 characteristics, including autophagy activation and reduced SASP secretion, improving healthspan in mice.

bioRxiv · Dec 8, 2022Physiology

Ultrasound-mediated mechanical forces selectively kill tumor cells

A. Tijore, F. Margadant, M. Yao, A. Hariharan, C. A. Z. Chew, S. Powell, G. K. Bonney, M. Sheetz

This paper shows low-frequency ultrasound selectively kills tumor cells via a calpain-dependent mitochondrial pathway involving Piezo1 channels, with minimal damage to normal cells in animal models and patient-derived organoids.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology