S. Jain

Discovering Symbolic Cognitive Models from Human and Animal Behavior

LLM-driven evolutionary program synthesis (CogFunSearch) discovers interpretable Python cognitive models that predict bandit-task choices of humans, rats and fruit flies better than leading hand-designed models.

FUSION: A web-based application for in-depth exploration of multi-omics data with brightfield histology

FUSION is a web-based tool that integrates spatial -omics data with histology to analyze tissue states and identify spatial linkages between molecular and histopathologic features.

Unravelling the Dynamics of Bacterial-Laden Respiratory Droplets: Epidemiological Transfer from Fomites to Susceptible Host

This study investigates how respiratory droplets containing Pseudomonas aeruginosa transfer pathogens via surfaces, finding increased viability with mucin and significant transfer at high humidity.

Microbial aerotrophy enables continuous primary production in diverse cave ecosystems

This study identifies aerotrophy as a primary energy source in caves, revealing microbial use of atmospheric trace gases for continuous primary production.

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

This study investigates the effects of TIMM50 deficiency in human fibroblasts and mouse neurons, finding reduced mitochondrial function and altered potassium channel levels linked to neurological symptoms.

A cross ancestry genetic study of psychiatric disorders from India

This study evaluates the predictive accuracy of polygenic scores for psychiatric disorders in an Indian population using European GWAS data, finding moderate-to-high accuracy for bipolar disorder but lower for OCD and externalizing traits.

Cellular uptake and viability switch in the properties of lipid-coated carbon quantum dots for potential bioimaging and therapeutics

This study examines how lipid-coating affects the uptake and viability of carbon quantum dots in cancer and epithelial cells, showing reduced toxicity and increased compatibility in non-cancerous cells.

A dynamin-like protein in the human malaria parasite plays an essential role in mitochondrial homeostasis and fission during asexual blood stages

This study identifies PfDyn2, a dynamin-like protein in P. falciparum, essential for mitochondrial fission and homeostasis during asexual blood stages of malaria.

Dynamic fibroblast-immune interactions shape wound healing after brain injury

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.

Azadirachta indica: derived, red-emitting, carbon nanoparticles for cellular bioimaging and potential therapeutics

This paper synthesizes red-emitting carbon nanoparticles from neem leaves and evaluates their cellular uptake and biocompatibility for bioimaging and therapeutic applications.

High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales

The paper tracks lineage evolution and transmission of Bacteroides thetaiotaomicron across hosts and ecological scales using genomic barcoding and whole-genome sequencing.

Weather-related changes in the dehydration of respiratory droplets on surfaces bolster bacterial endurance

This study shows that environmental conditions, particularly humidity, significantly affect the survivability of Pseudomonas Aeruginosa in respiratory droplets on surfaces.

XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Using a micro-device with a deformable ceiling to probe stiffness heterogeneities within 3D cell aggregates

This paper introduces a micro-device with a deformable ceiling to measure stiffness heterogeneities in 3D cell aggregates using compression and image correlation.

Klebsiella Pneumoniae turns more virulent under flow stresses in capillary like microchannels

This study shows that Klebsiella pneumoniae becomes more virulent under flow stresses in microchannels, as evidenced by increased proliferation in macrophages.

Unanticipated interacting features of human gut-associated lymphoid tissues link microbiota, intestinal immunity and autoimmunity

The paper identifies DN2 B cells in human GALT that interact with DC expressing DNASE1L3 and C1Q, linking microbiota, immunity, and autoimmunity.

Correlating Deep Learning-Based Automated Reference Kidney Histomorphometry with Patient Demographics and Creatinine

This paper uses deep learning to automate kidney histomorphometry and finds significant correlations between morphometric features and patient age, sex, and creatinine levels.

Cell-type-specific nuclear morphology predicts genomic instability and prognosis in multiple cancer types

The paper develops a deep learning pipeline for nucleus segmentation and featurization in cancer histology, linking nuclear morphology to genomic instability and prognosis across multiple cancer types.

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

This study identifies hybrid neutrophils with dendritic features in glioblastoma that suppress tumor growth and originate from skull bone marrow.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

Water chlorination increases the relative abundance of an antibiotic resistance marker in developing sourdough starters

This study shows that water chlorination increases the abundance of an antibiotic resistance marker in sourdough starters without significantly altering overall bacterial communities.

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

This study identifies the transsulfuration pathway as a targetable metabolic driver of glioblastoma invasion through multi-omic analyses of engineered biomaterials and patient biopsies.

Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus

The paper identifies potent human monoclonal antibodies against Sosuga virus, revealing epitope diversity and neutralization mechanisms.

Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

This study introduces two new parameters for analyzing anxiety and risk-taking in rats using the Elevated Plus Maze, revealing sex differences in spatial and temporal behavior.

Transcriptional profiles of functionally distinct HLADR+CD38+ CD8 T cells subsets from acute febrile dengue patients

This study identifies transcriptional differences among HLADR+CD38+ CD8 T cell subsets in dengue patients and shows similar expansion patterns across disease severity grades.

Application of Temperature-Responsive HIS-Tag Fluorophores to Differential Scanning Fluorimetry Screening of Small Molecule Libraries

The paper develops a high-throughput differential scanning fluorimetry assay using HIS-tag fluorophores to screen small molecule libraries for protein interactions.

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.