D. Mazel

The recombination efficiency of the bacterial integron depends on the mechanical stability of the synaptic complex

The paper investigates how the mechanical stability of the integron synaptic complex affects recombination efficiency in bacteria, finding a strong correlation between stability and efficiency.

Long-term evolution reveals the role of the circadian cycle in the environmental adaptation of cyanobacteria

The paper uses experimental evolution to show that circadian clock mutations in cyanobacteria enhance growth under continuous light by altering transcriptomic and metabolic responses.

MatP local enrichment delays segregation independently of tetramer formation and septal anchoring in Vibrio cholerae

The paper shows V. cholerae MatP structures and delays segregation of both chromosomes independently of tetramer formation and divisome interaction.

Chromosomal Integrons are Genetically and Functionally Isolated Units of Genomes

The paper deletes a chromosomal integron in Vibrio cholerae and shows it has no detectable effect on physiology, proving its genetic and functional isolation.

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

This study identifies uridine as a molecule that enhances aminoglycoside uptake in Gram-negative bacteria by activating carbohydrate transporters, improving antibiotic efficacy against resistant strains.

Identification of the active mechanism of aminoglycoside entry in V. cholerae through characterization of sRNA ctrR, regulating carbohydrate utilization and transport.

This paper identifies the active transport mechanism of aminoglycosides in V. cholerae by characterizing the sRNA ctrR, which regulates carbohydrate utilization and transport.

RavA-ViaA links Vibrio cholerae Cpx and Zra2 envelope stress to antibiotic response

This study shows that deletion of the ravA-viaA operon in Vibrio cholerae increases tolerance to aminoglycosides and affects polymyxin B sensitivity and vancomycin resistance by modulating Cpx and Zra2 two-component systems.

Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations

The paper measures single-cell antibiotic susceptibility in E. coli using microfluidic drops and image analysis, linking single-cell heterogeneity to population-level responses.

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

Chromosomal position of ribosomal protein genes impacts long term evolution of Vibrio cholerae.

This study shows that the chromosomal position of ribosomal protein genes in V. cholerae affects long-term evolutionary trajectories of growth rate and fitness.

Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

The paper identifies tRNA and rRNA modification genes as critical factors affecting bacterial response to sub-MIC antibiotics from different families.

Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae

This study shows that DNA methylation deficiency in Vibrio cholerae increases tolerance to aminoglycosides by upregulating chaperonin genes that mitigate antibiotic-induced protein misfolding.

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

The study shows that aminoglycosides can induce the SOS response in E. coli via a qnrD-plasmid, leading to qnrD transcription through NO accumulation driven by plasmid-encoded genes.

Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides.

The paper shows indole, induced by sublethal tobramycin, increases persistence to aminoglycosides in V. cholerae via RaiA-mediated ribosome storage.

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae.

This study shows that ribosomal protein gene location affects bacterial growth rate and macromolecular crowding in Vibrio cholerae.