Author

Z. Baharoglu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 4 Research Focus:drug response / drug discovery· 3 Organism:E. coli· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

D. Mazel· 9 shared M. Lang· 5 shared A. Babosan· 4 shared A. Carvalho· 4 shared E. Krin· 4 shared L. Fruchard· 2 shared A. Amoura· 1 shared A. Aristov· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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9 shared papersMicrobiology

D. Mazel

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

M. Lang, S. Renard, I. El-Meouche, A. Amoura, E. Denamur, T. Brosschot, M. Ingersoll, E. Bacque, D. Mazel, Z. Baharoglu

This study identifies uridine as a molecule that enhances aminoglycoside uptake in Gram-negative bacteria by activating carbohydrate transporters, improving antibiotic efficacy against resistant strains.

bioRxiv · Jul 31, 2023Microbiology

Identification of the active mechanism of aminoglycoside entry in V. cholerae through characterization of sRNA ctrR, regulating carbohydrate utilization and transport.

S. A. Pierle, M. Lang, R. Lopez-Igual, E. Krin, D. Fourmy, S. P. Kennedy, M.-E. Val, Z. Baharoglu, D. Mazel

This paper identifies the active transport mechanism of aminoglycosides in V. cholerae by characterizing the sRNA ctrR, which regulates carbohydrate utilization and transport.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

RavA-ViaA links Vibrio cholerae Cpx and Zra2 envelope stress to antibiotic response

E. Krin, A. Carvalho, M. Lang, A. Babosan, D. Mazel, Z. Baharoglu

This study shows that deletion of the ravA-viaA operon in Vibrio cholerae increases tolerance to aminoglycosides and affects polymyxin B sensitivity and vancomycin resistance by modulating Cpx and Zra2 two-component systems.

bioRxiv · Apr 24, 2023Microbiology

Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations

L. Le Quellec, A. Aristov, S. Guitierrez Ramos, G. Amselem, J. Bos, Z. Baharoglu, D. Mazel, C. Baroud

The paper measures single-cell antibiotic susceptibility in E. coli using microfluidic drops and image analysis, linking single-cell heterogeneity to population-level responses.

bioRxiv · Mar 8, 2023 · PreprintBioengineering

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

L. Fruchard, A. Babosan, A. Carvalho, M. Lang, B. Li, M. Duchateau, Q. Giai Gianetto, M. Matondo, F. Bonhomme, I. Hatin, H. Arbes, C. Fabret, E. Corler, G. Sanchez, V. MArchand, , Z. Baharoglu

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

bioRxiv · Sep 26, 2022Microbiology

Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

A. Babosan, L. Fruchard, E. Krin, A. Carvalho, D. Mazel, Z. Baharoglu

The paper identifies tRNA and rRNA modification genes as critical factors affecting bacterial response to sub-MIC antibiotics from different families.

bioRxiv · Feb 6, 2022Microbiology

Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae

A. Carvalho, D. Mazel, Z. Baharoglu

This study shows that DNA methylation deficiency in Vibrio cholerae increases tolerance to aminoglycosides by upregulating chaperonin genes that mitigate antibiotic-induced protein misfolding.

bioRxiv · Jul 29, 2021Microbiology

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

A. Babosan, D. Skurnik, A. Muggeo, G. Pier, T. Jove, M.-C. Ploy, S. Griveau, F. Bedioui, S. Vergnolle, S. Moussalih, C. de Champs, D. Mazel, T. Guillard, Z. Baharoglu

The study shows that aminoglycosides can induce the SOS response in E. coli via a qnrD-plasmid, leading to qnrD transcription through NO accumulation driven by plasmid-encoded genes.

bioRxiv · Apr 29, 2021Microbiology

Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides.

M. Lang, E. Krin, C. Korlowski, O. Sismeiro, H. Varet, J.-Y. Coppee, D. Mazel, Z. Baharoglu

The paper shows indole, induced by sublethal tobramycin, increases persistence to aminoglycosides in V. cholerae via RaiA-mediated ribosome storage.

bioRxiv · Nov 27, 2020Microbiology