C. Barton

Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling

This paper introduces copepodTCR, a tool for designing and interpreting TCR specificity assays, which efficiently identifies antigen-specific TCRs using combinatorial peptide pooling and Bayesian modeling.

Nanoscale 3D DNA tracing in single human cells visualizes loop extrusion directly in situ

This study uses nanoscale 3D imaging to show that DNA folds as flexible coils without loop extruding enzymes, but forms reproducible loops with Cohesin and CTCF.

An integrated gene catalog of the zebrafish gut microbiome reveals significant homology with mammalian microbiomes

The paper constructs a zebrafish gut microbiome gene catalog, showing significant homology with human and mouse microbiomes despite taxonomic differences.

The contribution of mitochondrial metagenomics to largescale data mining and phylogenetic analysis of Coleoptera

This study uses mitochondrial metagenomics and bulk sequencing to assemble a large phylogenetic tree of Coleoptera, showing congruence with Linnaean taxonomy but limited resolution for basal nodes.