W. Tang

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons

The paper shows that PIN2-mediated transient auxin flow creates auxin maxima at Arabidopsis cotyledon tips, coordinating pavement cell interdigitation.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres

This study shows that cell packing order in human lung alveolospheres increases with nucleus-to-cell size ratio, resembling a gas-to-liquid transition, and may regulate organ development and maturation.

The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

This study reconstructs the evolutionary history of Belidae weevils to show how their host plant shifts and dispersal were influenced by Gondwana breakup and angiosperm rise.

Characterization of ribosome stalling and no-go mRNA decay stimulated by the Fragile X protein, FMRP

This study shows FMRP stalls ribosomes and promotes no-go mRNA decay of specific transcripts, revealing a new role in FXS pathogenesis.

Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster

The paper identifies shared transcriptomic signatures of inflammaging across Drosophila melanogaster strains and shows machine learning can predict inflammatory age.

Thermo-Responsive Polymers Targeting Inflammation in Murine Colitis

This study develops thermo-responsive hydrogels that target inflamed colon mucosa for IBD treatment by exploiting charge-mediated interactions and thermo-responsiveness.

Floral scent emission of Epiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway

This study identifies a novel cytosol-localized geraniol biosynthesis pathway in Epiphyllum oxypetalum using volatilomic, transcriptomic, and biochemical approaches.

The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodies

This paper develops a proteomic toolbox to identify, quantify, and characterize polyclonal antibodies using RSV as a model, revealing key antibody isotypes and gene usage.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Effect of Intermittent Pneumatic Compression on Preventing Deep Vein Thrombosis Using Microfluidic Vein Chip

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

SERPINB3 induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

A Metabolomics Study of Thrombosis after Cardiac Surgery in Children with Congenital Heart Disease

This study identifies metabolites and pathways associated with thrombosis after cardiac surgery in children with congenital heart disease using untargeted metabolomics.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

This study shows cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase, independent of condensins, suggesting loop extrusion is a general mechanism for genome segregation.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

ABLs and TMKs are co-receptors for extracellular auxin

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource

The paper develops isogenic head and neck cancer cell line pairs to study Fanconi anemia-associated cancers and their treatment.

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

Persistence of SARS-CoV-2 neutralizing antibodies longer than 13 months in naturally-infected, captive white-tailed deer (Odocoileus virginianus), Texas

The study tracks SARS-CoV-2 neutralizing antibody persistence in white-tailed deer, finding antibodies lasted at least 13 months in most animals, with some temporary increases in titers.

A Genome-scale Screen Reveals ANTXR1, Heparan Sulfate and Neu5Gc as Host Factors mediating Seneca Valley virus Entry into Porcine Cells

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

Additive and Dominant Loci Jointly Pyramiding the Grain Quality of Hybrid Rice

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.