P. Reinke

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

This study shows that matching or engineering HLA-I and HLA-II improves the efficacy of allogeneic regulatory T cells for immunoregulation.

This paper combines CRISPR nucleases to simultaneously knock-in and base edit CAR T cells, reducing translocations to 1.5% and improving safety.

This study shows that hiPSC-derived renal cells become less immunogenic as they mature, with implications for improving immune tolerance in regenerative therapies.

This paper presents a virus-free method to generate CAR T cells by inserting CARs into the TRAC locus using CRISPR-Cas and HDR, achieving up to 68% TCR-to-CAR replacement.

This study compares prophylactic and pre-emptive strategies for preventing CMV syndrome in renal transplant patients, finding that the prophylactic strategy impairs kidney function in females.

The paper investigates factors affecting BKV clearance in kidney transplant patients, finding that T-cell receptor diversity and exhaustion status, not clone numbers, correlate with clearance duration.

This paper develops a novel method using HLA class 1 single antigen bead signatures to predict acute cellular rejection risk pre-transplant with high accuracy.

The paper identifies a widespread memory/effector T cell response and regulatory T cell presence against SpCas9 in healthy humans, with implications for gene therapy.