E. W. Roberts

Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

The paper identifies specialized Tfh1 and Tfh2 subsets driving type-1 and type-2 humoral responses using single-cell transcriptomics and machine learning.

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

Impact of Protein Identity on Tumor-Associated Antigen Uptake into Infiltrating Immune Cells: A Comparison of Different Fluorescent Proteins as Model Antigens

This study compares six fluorescent proteins as model antigens to assess their uptake and distribution in tumor-infiltrating immune cells and draining lymph nodes, finding variability in detection and transport based on fluorophore properties.

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

The paper shows myeloid cells transfer tumor antigen-laden vesicles to APCs, directing T cell responses away from memory phenotypes.

Chimeric antigen receptors that trigger phagocytosis

This paper introduces CAR-Ps, chimeric antigen receptors that direct macrophages to engulf specific targets like cancer cells, showing over 40% reduction in cancer cell numbers in co-culture.