Author

C. Bergh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Approach:deep learning· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

E. Lindahl· 4 shared R. J. Howard· 3 shared U. Rovsnik· 2 shared A. Hanke· 1 shared A. Martel· 1 shared A. R. Beccari· 1 shared A. Zaliani· 1 shared B. P. Joseph· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiophysics

E. Lindahl

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Author profile →

4 papers

Recent·Most cited

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

C. Bergh, U. Rovsnik, R. J. Howard, E. Lindahl

The paper identifies lipid binding sites in the GLIC ion channel using cryo-EM and simulations, revealing state-dependent interactions in both closed and open conformations.

bioRxiv · Jan 6, 2023Biophysics

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

M. Lycksell, U. Rovsnik, C. Bergh, N. T. Johansen, A. Martel, L. Porcar, L. Arleth, R. J. Howard, E. Lindahl

This study uses small-angle neutron scattering to examine conformational changes in the bacterial ion channel GLIC under resting and activating conditions, finding no evidence for divergent mechanisms.

bioRxiv · Apr 10, 2021Biophysics

Markov state models of proton- and gate-dependent activation in a pentameric ligand-gated ion channel

C. Bergh, S. A. Heusser, R. J. Howard, E. Lindahl

The paper constructs Markov state models of GLIC channel gating using enhanced sampling and functional recordings, revealing protonation and mutation effects on conformational transitions and symmetrization.

bioRxiv · Mar 12, 2021Biophysics

A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics

J. Gossen, S. Albani, A. Hanke, B. P. Joseph, C. Bergh, M. Kuzikov, E. Costanza, C. Manelfi, P. Storici, P. Gribbon, A. R. Beccari, C. Talarico, F. Spyrakis, E. Lindahl, A. Zaliani, , G. Rossetti

The paper identifies a blueprint for high affinity SARS-CoV-2 Mpro inhibitors by analyzing protein dynamics and redefining druggability through virtual screening and pharmacophore modeling.

bioRxiv · Dec 14, 2020Biophysics