Author

S. Albani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Assay:flow cytometry· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

L. Lai· 3 shared C. Chua· 2 shared G. Rossetti· 2 shared J. Y. Leong· 2 shared P. Chen· 2 shared A. A. Widjaja· 1 shared A. Boltjes· 1 shared A. Hanke· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

L. Lai

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Author profile →

6 papers

Recent·Most cited

Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7

S. Albani, V. S. B. Eswaran, A. Piergentili, P. C. T. d. Souza, A. Lampert, G. Rossetti

This study shows that cholesterol depletion alters Nav1.7 structure and function, affecting its gating and drug response, with implications for pain management.

bioRxiv · Feb 21, 2024Physiology

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

G. Mijnheer, N. H. Servaas, J. Y. Leong, A. Boltjes, E. Spierings, P. Chen, L. Lai, A. Petrelli, S. Vastert, R. J. De Boer, S. Albani, A. Pandit, F. van Wijk

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

bioRxiv · Feb 10, 2022Immunology

A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics

J. Gossen, S. Albani, A. Hanke, B. P. Joseph, C. Bergh, M. Kuzikov, E. Costanza, C. Manelfi, P. Storici, P. Gribbon, A. R. Beccari, C. Talarico, F. Spyrakis, E. Lindahl, A. Zaliani, , G. Rossetti

The paper identifies a blueprint for high affinity SARS-CoV-2 Mpro inhibitors by analyzing protein dynamics and redefining druggability through virtual screening and pharmacophore modeling.

bioRxiv · Dec 14, 2020Biophysics

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

B. Ng, J. Dong, S. Viswanathan, A. A. Widjaja, B. S. Paleja, E. Adami, N. S. J. Ko, M. Wang, S. Lim, J. Tan, S. P. Chothani, S. Albani, S. Schafer, S. A. Cook

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

bioRxiv · Oct 11, 2019Cell Biology

An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal

J. Y. Leong, P. Chen, J. G. Yeo, F. Ally, C. Chua, S. N. Hazirah, S. L. Poh, L. Pan, L. Lai, E. S. C. Lee, L. D. T. Bathi, Paediatric Rheumatology Collaborative Study, T. Arkachaisri, D. Lovell, S. Albani

The paper identifies an inflammatory CD4 T cell subset and transcriptomic signatures in JIA patients in remission that predict relapse after anti-TNFα withdrawal.

bioRxiv · May 31, 2019Immunology

Systemic sclerosis is a disease of a prematurely senescent, inflammatory and activated immunome

B. Paleja, A. Low Hsiu Ling, P. Kumar, S. Saidin, A. Lajam, S. Nur Hazirah, C. Chua, L. Lai, S. Albani

This study identifies altered immune architecture in systemic sclerosis, showing premature senescence of immune cells due to chronic stimulation.

bioRxiv · May 16, 2019 · PreprintImmunology