L. Arleth

The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase

This study investigates how linker conformation affects the performance and stability of a two-domain lytic polysaccharide monooxygenase by analyzing wild-type and engineered variants.

mPD5, a peripherally restricted PICK1 inhibitor for treating chronic pain

This paper develops mPD5, a peripherally restricted PICK1 inhibitor that reduces chronic pain and associated symptoms in mice without significant side effects.

The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

This study shows that the prolactin receptor forms a co-structure with JAK2 and PI(4,5)P2, enabling signal transduction by stabilizing the receptor's disordered domain.

Refining structural models of membrane proteins withdisordered domains in phospholipid nanodiscs

This study refines structural models of membrane proteins with disordered domains using small-angle x-ray scattering in nanodiscs and introduces new computational methods and software.

Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation

This study investigates the conformational dynamics of CorA, revealing Mg2+-dependent conformational equilibria and dynamic behavior through SANS, MD simulations, and NMR.

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

This study uses small-angle neutron scattering to examine conformational changes in the bacterial ion channel GLIC under resting and activating conditions, finding no evidence for divergent mechanisms.

Bi-directional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners

This study identifies the minimal peptide responsible for stargazin-mediated LLPS of PSD-95 and shows that pharmacological inhibitors can promote LLPS formation.

Properdin oligomers adopt rigid extended conformations supporting function

This study shows properdin oligomers adopt rigid extended conformations that are essential for their function in the complement cascade.

Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

This study examines the structural formation of lipid-bound ApoE3 particles, revealing elliptical disc shapes and differences in morphology between full-length and truncated forms.

Ab-initio determination of the shape of membrane proteins in a nanodisc

The paper introduces Marbles, a software that uses SAXS data to predict the shape of membrane proteins in nanodiscs, validated on toy models and proteins with varying geometries.

Order and disorder - an integrative structure of the full-length human growth hormone receptor

This study determines the structure of the full-length human growth hormone receptor using integrated SAXS, X-ray diffraction, NMR, and molecular dynamics simulations, revealing a flexible ensemble of domains.

Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

This study integrates NMR, SAXS, SANS, and molecular dynamics simulations to characterize the structure and dynamics of two nanodiscs, revealing conformational heterogeneity and lipid ordering differences.

Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

The paper combines molecular dynamics simulations with small-angle scattering data to study multi-domain proteins, showing how refining simulations against SAXS data improves agreement with experiments.

PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates

The paper introduces PSX, a software tool for calculating deuterium-exchange effects in SANS measurements from protein coordinates, showing that the common 90% exchange assumption is often an overestimate.

Structure and dynamics of the central lipid pool and protein components of the bacterial holo-translocon

The paper investigates the structure and dynamics of the bacterial holo-translocon using SANS and molecular dynamics simulations, revealing a central lipid core involved in membrane protein insertion.