Author

C. Beusch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Saei· 3 shared M. Gaetani· 3 shared P. Sabatier· 3 shared A. Chernobrovkin· 2 shared A. Vegvari· 2 shared R. Zubarev· 2 shared A.-G. Thorsell· 1 shared B. Zhang· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiochemistry

A. A. Saei

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA)

A. A. Saei, C. Beusch, P. Sabatier, J. Astorga Wells, A. Chernobrovkin, S. Rodin, K. Nareoja, A.-G. Thorsell, T. Karlberg, Q. Cheng, S. L. Lundstrom, M. Gaetani, A. Vegvari, E. S. J. Arner, H. Schuler, R. Zubarev

SIESTA identifies and prioritizes enzyme substrates by detecting thermal stability changes caused by post-translational modifications, demonstrating effectiveness across multiple enzyme systems.

bioRxiv · Jan 21, 2020Biochemistry

Proteome Integral Stability Alteration assay dramatically increases throughput and sensitivity in profiling factor-induced proteome changes

M. Gaetani, P. Sabatier, A. A. Saei, C. Beusch, Z. Yang, S. Lundstrom, R. A. Zubarev

The paper introduces the PISA assay, which improves throughput and sensitivity in profiling factor-induced proteome stability changes by avoiding curve fitting and enabling parameter variation analysis.

bioRxiv · Dec 13, 2018Cancer Biology

ProTargetMiner: A proteome signature library of anticancer molecules for functional discovery

A. A. Saei, A. Chernobrovkin, P. Sabatier, B. Zhang, C. Beusch, U. Guler Tokat, M. Gaetani, A. Vegvari, R. Zubarev

ProTargetMiner provides a proteome signature library of anticancer molecules in A549 cells, revealing drug targets, co-regulation networks, and essential proteins for cellular functions.

bioRxiv · Sep 18, 2018Cell Biology