Q. Cheng

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

Molecular Architecture of Chitin and Chitosan-Dominated Cell Walls in Zygomycetous Fungal Pathogens by Solid-State NMR

This study uses solid-state NMR to analyze the molecular structure of cell walls in Mucorales fungi, revealing the composition and organization of chitin, chitosan, and associated polysaccharides.

Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy

This study uses targeted mRNA-LNPs to deliver IL-15 superagonists, improving anti-tumor efficacy while reducing toxicity compared to existing therapies.

THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research

THER is a web tool that integrates hypoxia-related transcriptomic data to analyze tumor hypoxia mechanisms and drug responses.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

Creating a thermostable beta-glucuronidase switch for homogeneous immunoassay by disruption of conserved salt bridges at diagonal interfaces

This paper develops a thermostable beta-glucuronidase switch by disrupting salt bridges, enhancing signal-to-background ratio for immunosensors.

Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis

This study identifies how Rabphilin 3A binds the N-peptide of SNAP-25 to enhance SNARE complex assembly, facilitating vesicle exocytosis.

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

Structural Basis of Complex Formation Between Mitochondrial Anion Channel VDAC1 and Hexokinase-II

This study investigates the structural basis of the HKII/VDAC1 complex formation using simulations and electrophysiological measurements, revealing partial blockade of VDAC1 and phosphorylation-dependent disruption of binding.

Dexmedetomidine mediates microRNA-185 to suppress ovarian cancer growth via inhibiting the SOX9/Wnt/β-catenin signaling pathway

This study identifies HAND2-AS1 as a tumor suppressor in cervical cancer by regulating miR-21 and ALEX1 to inhibit proliferation and EMT.

System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA)

SIESTA identifies and prioritizes enzyme substrates by detecting thermal stability changes caused by post-translational modifications, demonstrating effectiveness across multiple enzyme systems.

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

This study identifies stage-specific differentiation delays caused by GATA1s in megakaryocytes, leading to increased immature cells and altered gene expression.