Author

A. Vegvari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6 Biochemistry· 4 Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 12 Organism:human· 11 Approach:experimental assay· 10 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3

Frequent Co-Authors

U. Neogi· 6 shared A. A. Saei· 5 shared F. Mikaeloff· 5 shared J. E. Rodriguez· 5 shared M. Gaetani· 5 shared S. Gupta· 5 shared A. Mirazimi· 4 shared E. Saccon· 4 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

U. Neogi

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

Z. Meng, A. A. Saei, X. Zhang, H. Lyu, H. Gharibi, S. L. Lundstrom, A. Vegvari, M. Gaetani, R. A. Zubarev

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

bioRxiv · Feb 14, 2024 · PreprintBiochemistry

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

A. A. Saei, A. Lundin, H. Lyu, H. Gharibi, H. Luo, J. Teppo, X. Zhang, M. Gaetani, A. Vegvari, R. Holmdahl, S. P. Gygi, R. A. Zubarev

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

bioRxiv · Aug 31, 2023Biochemistry

Amino acid usage and tRNA expression underlies proteome adaptation in Plasmodium falciparum

Q. Li, L. Vetter, Y. Veith, E. Christ, A. Vegvari, C. Sahin, U. Ribacke, M. Wahlgren, J. Ankarklev, O. Larsson, S. C. L. Chan

The paper shows that Plasmodium falciparum adjusts its tRNA profile and codon usage to adapt to amino acid availability from hemoglobin digestion, affecting protein synthesis and proliferation.

bioRxiv · Mar 20, 2023Microbiology

Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptation

A. M. Muktadir Shafi, A. Vegvari, R. Zubarev, C. Penha-Goncalves

This study shows that Type I interferon signaling in brain endothelial cells exposed to malaria parasites enhances antigen presentation and disrupts the endothelial barrier, contributing to cerebral malaria pathology.

bioRxiv · Nov 26, 2022Immunology

Mapping the GALNT1 substrate landscape with versatile proteomics tools

A. A. Saei, S. L. Lundstrom, H. Lyu, H. Gharibi, W. Lu, P. Fang, X. Zhang, Z. Meng, J. Wang, M. Gaetani, A. Vegvari, S. P. Gygi, R. A. Zubarev

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

bioRxiv · Aug 24, 2022 · PreprintBiochemistry

Single Cell Chemical Proteomics (SCCP) Interrogates the Timing and Heterogeneity of Cancer Cell Commitment to Death

A. Vegvari, J. E. Rodriguez, R. Zubarev

This study applies single cell chemical proteomics to analyze the time-dependent and heterogeneous response of cancer cells to anticancer drugs.

bioRxiv · Apr 21, 2021Cancer Biology

Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

S. Krishnan, H. Nordqvist, A. T. Ambikan, S. Gupta, M. Sperk, S. Svensson-Akusjarvi, F. Mikaeloff, R. Benfeitas, E. Saccon, S. M. Ponnan, J. E. Rodriguez, N. Nikouyan, A. Odeh, G. Ahlen, M. Asghar, , U. Neogi

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

bioRxiv · Feb 24, 2021Microbiology

Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

E. Saccon, F. Mikaeloff, P. Figueras Ivern, A. Vegvari, A. Sonnerborg, U. Neogi, R. van Domselaar

This study shows that granzyme M from cytotoxic lymphocytes cleaves HIV-1 Gag, potentially controlling infection without killing infected cells.

bioRxiv · Feb 24, 2021Immunology

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

X. Chen, E. Saccon, K. S. Appelberg, F. Mikaeloff, J. E. Rodriguez, B. S. Vinhas, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

bioRxiv · Feb 4, 2021Microbiology

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo Hemorrhagic Fever Viruses for novel therapeutic target

U. Neogi, N. Elaldi, S. Appelberg, A. Ambikan, E. Kennedy, S. D. Dowall, B. K. Bagci, S. Gupta, J. E. Rodriguez, S. Svensson-Akusjärvi, V. Monteil, A. Vegvari, R. Benfeitas, A. Banerjea, F. Weber, , A. Mirazimi

This study uses multi-omics approaches to analyze host-viral interactions in CCHFV infection, identifying metabolic reprogramming and interferon-mediated antiviral mechanisms as potential therapeutic targets.

bioRxiv · Dec 10, 2020Microbiology

Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

E. Saccon, X. Chen, F. Mikaeloff, J. E. Rodriguez, L. Szekely, B. S. Vinhas, S. Krishnan, S. Byrareddy, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

bioRxiv · Aug 28, 2020Microbiology

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

S. Appelberg, S. Gupta, A. T. Ambikan, F. Mikaeloff, A. Vegvari, S. Svensson Akusjarvi, R. Benfeitas, M. Sperk, M. Stahlberg, S. Krishnan, K. Singh, J. M. Penninger, A. Mirazimi, U. Neogi

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

bioRxiv · Apr 30, 2020Microbiology

System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA)

A. A. Saei, C. Beusch, P. Sabatier, J. Astorga Wells, A. Chernobrovkin, S. Rodin, K. Nareoja, A.-G. Thorsell, T. Karlberg, Q. Cheng, S. L. Lundstrom, M. Gaetani, A. Vegvari, E. S. J. Arner, H. Schuler, R. Zubarev

SIESTA identifies and prioritizes enzyme substrates by detecting thermal stability changes caused by post-translational modifications, demonstrating effectiveness across multiple enzyme systems.

bioRxiv · Jan 21, 2020Biochemistry

ProTargetMiner: A proteome signature library of anticancer molecules for functional discovery

A. A. Saei, A. Chernobrovkin, P. Sabatier, B. Zhang, C. Beusch, U. Guler Tokat, M. Gaetani, A. Vegvari, R. Zubarev

ProTargetMiner provides a proteome signature library of anticancer molecules in A549 cells, revealing drug targets, co-regulation networks, and essential proteins for cellular functions.

bioRxiv · Sep 18, 2018Cell Biology