R. Zubarev

This study shows that Type I interferon signaling in brain endothelial cells exposed to malaria parasites enhances antigen presentation and disrupts the endothelial barrier, contributing to cerebral malaria pathology.

This paper introduces a method to measure drug residence times on targets by analyzing protein solubility changes after drug removal, enabling better target characterization for drug development.

The paper finds unexpectedly high deuterium levels in proline and hydroxyproline residues of seal bone collagen, challenging assumptions about diet and environmental influences on isotopic signatures.

This study applies single cell chemical proteomics to analyze the time-dependent and heterogeneous response of cancer cells to anticancer drugs.

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

SIESTA identifies and prioritizes enzyme substrates by detecting thermal stability changes caused by post-translational modifications, demonstrating effectiveness across multiple enzyme systems.

ProTargetMiner provides a proteome signature library of anticancer molecules in A549 cells, revealing drug targets, co-regulation networks, and essential proteins for cellular functions.