Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia
A. F. Rendeiro, T. Krausgruber, N. Fortelny, F. Zhao, T. Penz, M. Farlik, L. C. Schuster, A. Nemc, S. Tasnady, M. Reti, Z. Matrai, D. Alpar, C. Bodor, C. Schmidl, C. Bock
This study maps chromatin changes and single-cell immune profiles during ibrutinib treatment in CLL, identifying a shared regulatory program and patient-specific response dynamics.
bioRxiv · Apr 3, 2019Cancer Biology