T. Krausgruber

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

This study uses scRNA-seq to identify two distinct subsets of pathogenic Th2 cells in allergic asthma and establishes an in vitro model to study their regulation.

This study uses scRNA-seq to analyze early hyperglycaemia responses in multiple organs of a mouse model, identifying conserved and organ-specific transcriptional changes linked to diabetes complications.

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.

This study maps chromatin changes and single-cell immune profiles during ibrutinib treatment in CLL, identifying a shared regulatory program and patient-specific response dynamics.

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.